Against the backdrop of accelerated development in vocational undergraduate education and the advancement of the Healthy China strategy, the cultivation of nursing talents requires a high-quality transformation characterized by “integrating moral and technical skills, and unifying knowledge with practice.” The concept of “ideological and political education in courses” has evolved from the question of “whether to implement it” to the stage of “how to deepen and solidify its implementation.” This paper, from the perspective of “holistic education”, focuses on the characteristics of vocational undergraduate nursing programs and the entire training process. It analyzes issues in the construction of ideological and political education in courses, such as the disconnect between ideological and political education and professional training, gaps in clinical practice, and an evaluation system that prioritizes knowledge over action. The paper proposes a comprehensive educational model covering the entire process, from “training programs—curriculum systems—classroom teaching—on-campus training—clinical internships—second classroom—quality evaluation—collaborative mechanisms.” Additionally, the paper proposes implementation strategies from three dimensions: a three-stage progression path (ideological and political courses—ideological and political education in courses—clinical ideological and political education), the construction of collaborative educational communities, and the development of a digital and intelligent evaluation system. These strategies provide actionable and replicable practical paradigms for the systematic construction of ideological and political education in vocational undergraduate nursing programs.