Colombia has long been recognized as one of the world’s primary producers of cocaine, and its geographic location has made it a crucial hub in the global drug trade. the consequences of Colombia’s drug trade extend beyond domestic issues and directly affect the national security interests of the United States.In response to these challenges, the United States government has maintained long-term cooperation with the Colombian government, supporting various anti-drug strategies aimed at reducing narcotics production and dismantling trafficking networks. These efforts have included military assistance, intelligence cooperation, and large-scale development programs such as Plan Colombia.This paper examines the evolution of U.S. drug war policies in Colombia from the perspective of national security, By exploring both domestic and international dimensions of the drug war, this study seeks to provide a clearer understanding of the broader geopolitical implications of U.S.–Colombia cooperation in combating narcotics trafficking.