The rapid development of artificial intelligence technology has provided brand-new ideas and methods for computer application software development, becoming an important driving force to promote the intelligence and efficiency of software development. Starting from the overall concepts of artificial intelligence technology and computer application software development, this paper systematically analyzes the application of artificial intelligence in computer software development, and elaborates on the functions of artificial immune technology, neural network technology, Agent technology, and expert systems in software development. It not only provides theoretical support for the application of artificial intelligence technology in software development but also offers operable strategic suggestions for practice, which is of great guiding significance for improving software development efficiency and optimizing software quality.