"The major ideological and political education course" is the core carrier for cultivating moral character in universities in the new era, and high-quality party building provides crucial support for it. This article, targeting private undergraduate vocational colleges, takes party affairs training as the starting point, examines the relationship between party building and the "major ideological and political education course", and constructs a path for leading the "major ideological and political education course" with party building from four dimensions: curriculum, teachers, practice, and mechanism. By exploring red resources, integrating local practices, and establishing a collaborative network, etc., the problem of the compatibility between the "major ideological and political education course" and vocational education is addressed, providing a reference for cultivating new era individuals.