Volume 10,Issue 4
To Explore the Efficacy of Fuzheng Jieyu Decoction Combined with Recombinant Human Interferon a2b Vaginal Effervescent Capsules (Xinfuning) in the Treatment of Cervical HPV Infection
Objective: To study the therapeutic effect of Fuzheng Jieyu Decoction combined with recombinant human interferon α2b vaginal effervescent capsules (Xinfuning) on patients with cervical human papillomavirus (HPV) infection. Methods: 86 patients with cervical HPV infection who received treatment in our hospital from January 2025 to December 2025 were selected and divided into a combination group and a single drug group using the random number table method, with 43 cases in each group. The single-drug group was treated with recombinant human interferon α2b vaginal effervescent capsules (Xinfuning), and the combination group was treated with Fuzheng Jieyu Decoction orally on the basis of the single-drug group. The therapeutic effects of the two groups were compared. Results: The HPV negative conversion rate and the effective rate of improving cervical inflammation in the combination group were higher than those in the single-drug group. The white blood cell count of cervical secretions and cervical mucosal congestion score after treatment were lower than those of the single-drug group. The vaginal cleanliness was better than that of the single-drug group, and the complication rate was lower than that of the single-drug group (p < 0.05). Conclusion: Fuzheng Jieyu Decoction combined with recombinant human interferon α2b vaginal effervescent capsules (Xinfuning) can effectively increase the virus negative conversion rate, improve cervical inflammation indicators, and reduce the probability of treatment-related complications in the treatment of cervical HPV infection, which has good clinical application value.
[1] Wang R, Yang J, Zhang P, et al., 2025, Comparison of the Effects of Baofukang Suppository, Xinfuning and Anti-HPV Biological Protein Dressings in the Treatment of Cervical Precancerous Lesions Combined with High-Risk HPV Infection. Chinese Journal of Drug Abuse Prevention and Control, 31(04): 687–690.
[2] He F, Ou Y, Ding Y, et al., 2024, Clinical Study of Fuzheng Jieyu Decoction Combined with Recombinant Human Interferon in the Treatment of Chronic Cervicitis Combined eith High-Risk HPV Infection. Shaanxi Traditional Chinese Medicine, 45(05): 605–609.
[3] Hou F, Xiong Z, Zou H, 2023, Clinical Observation on the Treatment of High-Risk HPV Infection with Banzhilian Heermiao Decoction Combined with Xinfuning. Guangming Traditional Chinese Medicine, 38(20): 4024–4027.
[4] Guo L, Ma Y, Chen X, 2023, Effectiveness of HPV Bioprotein Dressing in the Treatment of Cervical Precancerous Lesions Combined with High-Risk HPV Infection. Chinese Journal of Family Planning, 31(05): 1047–1051.
[5] Cheng X, Wang X, Qian X, 2022, The Efficacy and Mechanism of Baofukang Suppository Combined with Xinfuning in the Treatment of Patients with HPV Infection. World Journal of Integrated Traditional Chinese and Western Medicine, 17(11): 2255–2259.
[6] Wu Z, Lu R, Li W, et al., 2022, Observation on the Efficacy of Huashi Jiedu Decoction Combined with Xinfuning in the Treatment of Cervical Intraepithelial Neoplasia Combined with High-Risk HPV Infection. Journal of Harbin Medical University, 56(02): 151–155.
[7] Yang L, 2022, The Efficacy of Xinfuning on Cervical Diseases Related to HPV Infection and Its Impact on Immunity. Famous Doctors, (04): 183–185.
[8] Yin B, Zhou L, Wang F, et al., 2021, The Effect and Mechanism of Baofukang Suppository Combined with Xinfuning in the Treatment of Human Papillomavirus Infection. Chinese Journal of Family Planning, 29(09): 1858–1863.
[9] Xia T, 2021, Observation on the Efficacy of Xinfuning in the Treatment of Chronic Cervicitis Accompanied by HR-HPV Infection. Chinese Community Physicians, 37(16): 46–47.
[10] Jiang Y, 2021, Observation on the Effect and Prognosis of Xinfuning Combined with Dingjunsheng in Anti-HPV Infection. Medical Diet Therapy and Health, 19(05): 79–80.