Volume 10,Issue 4
Research on the Immune Mechanisms of Cognitive Impairment in Depression
Major Depressive Disorder (MDD) is a prevalent mental disorder characterized primarily by persistent feelings of sadness. Over the past decade, accumulating evidence has demonstrated that patients with depression exhibit cognitive impairments, such as deficits in attention, learning and memory, and executive function. Cognitive impairment is a significant symptom and prognostic indicator of depression, and can manifest at any stage of MDD onset. Research over the past two decades has indicated a close relationship between the immune system and the onset of depression. This article will elucidate the immunological mechanisms underlying cognitive impairment in depression from the perspectives of brain immune mechanisms, systemic (peripheral) immune mechanisms, and their bidirectional regulation, aiming to provide novel theoretical insights for the treatment of cognitive impairment in depression.
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