Objective: To study the clinical effect of cesarean section combined with myomectomy (LM) in the treatment of pregnancy complicated with uterine fibroids. Methods: 152 patients with pregnancy complicated with uterine fibroids admitted to our hospital from July 2022 to July 2024 were selected and divided into two groups according to the different surgical methods, 76 cases in each group. The control group was given conventional cesarean section for delivery, and the uterine fibroids were removed at a selected time after the body recovered, while the experimental group was given cesarean section combined with uterine fibroids removal. The clinical therapeutic effect, complication rate and surgical indicators of the two groups were compared. Results: compared with the control group, the total effective rate of the experimental group was higher (p < 0.05); Compared with the control group, the operation time of the experimental group was longer (p < 0.05), while there was no significant difference in the amount of bleeding, lochia clearance time and other indicators between the two groups (p > 0.05); The incidence of complications in the experimental group was lower than that in the control group (p < 0.05). Conclusion: cesarean section combined with myomectomy for pregnant women with uterine fibroids during delivery can improve the treatment effect and reduce the incidence of complications on the premise of ensuring the safety of operation, which has high clinical application value.