This study examines the limitations of detecting reinfection through dynamic changes in serum Helicobacter pylori (Hp) IgG antibody titers and proposes targeted optimization strategies. The analysis identifies three core challenges: antibody characteristics, diagnostic criteria, and individual variations. Clinical practice demonstrates that persistent antibody positivity, inconsistent diagnostic standards, and variations in immune responses and mucosal conditions are key obstacles. By optimizing monitoring timelines, establishing baseline calibrations, creating unified technical protocols, and developing multidimensional evaluation systems, the accuracy of reinfection detection can be significantly improved. Dynamic monitoring of serum Hp-IgG antibody titers requires standardized procedures and comprehensive assessment frameworks to provide reliable clinical support for reinfection prevention.