Volume 11,Issue 2
Experimental Study on the Repair of Spinal Cord Injury by Induced Pluripotent Stem Cell (IPSC) Transplantation
Objective: To investigate the reparative effects of induced pluripotent stem cell (iPSC) transplantation on spinal cord injury (SCI) and its influence on neurological functional recovery. Methods: Based on previous animal experimental studies of SCI, the survival, differentiation characteristics, and motor function changes following transplantation of iPSC-derived neural stem cells were analyzed. Behavioral assessments and histological methods were employed to evaluate the therapeutic effects of transplantation. Results: After transplantation, iPSCs were able to survive in the injured spinal cord and differentiate into neurons, astrocytes, and oligodendrocytes. Compared with the control group, animals in the transplantation group showed significantly improved motor function scores (P < 0.05), accompanied by enhanced axonal regeneration and remyelination in the injured area. Conclusion: iPSC transplantation exerts a positive effect on promoting structural repair and functional recovery after spinal cord injury, indicating its potential therapeutic value.
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