Objective: To explore the application value of the Objective Structured Clinical Examination (OSCE) combined with scenario simulation teaching mode in the clinical teaching of burn care, and to provide empirical data for improving the clinical practice ability and comprehensive quality of nursing students. Methods: Sixty nursing students who were on internship in the burn department of a tertiary hospital from September 2024 to June 2025 were selected as the research subjects. They were randomly divided into an experimental group and a control group using a random number table. The experimental group adopted the OSCE combined with scenario simulation teaching method, constructing six standardized stations covering burn wound assessment, fluid resuscitation during shock period, infection control, etc. Each station was set up with real case scenarios, high-fidelity burn models, and standardized patients, and a closed-loop training method of "assessment, operation, feedback" was adopted. The control group used traditional teaching methods, mainly bedside demonstration and theoretical lectures. The teaching period lasted for 8 weeks. The assessment included theoretical examination (out of 100 points), operation skills assessment (including five core skills such as wound debridement and dressing change, and bandaging and fixation, each worth 20 points), and clinical comprehensive ability assessment (using the nursing ability scale, including six dimensions such as condition observation and emergency handling, evaluated through a teaching satisfaction questionnaire (Likert 5-point scale). Results: The experimental group had significantly higher scores in theoretical examination and operation skills assessment, especially in the standardization of debridement procedures (94.2 ± 2.8 vs. 75.6 ± 5.1) and pain management measures (91.5 ± 3.1 vs. 73.8 ± 4.9). During the clinical comprehensive ability assessment, the experimental group showed better performance in teamwork and higher satisfaction with the teaching method. Conclusion: The integration of OSCE and scenario simulation teaching can systematically enhance the quality of burn care clinical teaching. Through the organic combination of standardized assessment and immersive training, it can effectively improve the clinical thinking, operational accuracy, and adaptability of nursing students, and has significant promotion significance for cultivating high-quality burn care talents.