Volume 11,Issue 2
Insights into Sarcopenic Obesity Mechanisms: A Focus on Bidirectional Adipose-Muscle Interactions
Sarcopenic obesity (SO) is a major health issue in aging societies, and its prevalence continues to rise with the global aging process. Compared with sarcopenia or obesity alone, SO is associated with aggravated metabolic disorders and a significantly elevated risk of adverse outcomes. Traditional studies have mostly investigated sarcopenia and obesity as independent pathological conditions; however, recent evidence has revealed a close bidirectional regulatory network between adipose tissue and skeletal muscle, and the imbalance in their crosstalk constitutes the core pathological basis for the occurrence and progression of SO. From the perspective of adipose-skeletal muscle crosstalk, this paper systematically reviews the conceptual framework and bidirectional signaling network in this field, aiming to break through traditional research paradigms and provide an integrated theoretical framework for optimizing diagnostic criteria, identifying biomarkers, and developing precise intervention strategies.
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