Volume 11,Issue 4
Research Progress on the Function and Application of VCP in Various Cancers
Abstract: Valosin-containing protein (VCP/p97) is a core member of the AAA + ATPase family and functions as a "ubiquitin-dependent molecular chaperone/segregase, " playing a pivotal role in endoplasmic reticulum-associated degradation (ERAD), protein homeostasis, DNA damage response, organelle quality control (mitochondria/lysosomes), and signaling pathway regulation. Recent basic research has demonstrated that VCP is closely associated with malignant progression in various solid tumors by regulating processes such as tumor cell stress adaptation, proliferation and survival, invasion and metastasis, dryness maintenance, and chemoradiotherapy response, and exhibits "non-pharmacological" applications including prognostic evaluation and molecular subtyping. This article focuses on the expression characteristics, key mechanisms, and application research progress of VCP in five tumor types: esophageal cancer, gastric cancer, colorectal cancer, prostate cancer, and lung cancer, aiming to provide references for further mechanistic elucidation and clinical translation.
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