Volume 11,Issue 5
Research Progress on Risk Prediction and Preventive Measures for Contrast-Induced Nephropathy During Cerebrovascular Interventional Procedures
To prevent the occurrence of contrast-induced nephropathy during cerebrovascular interventional procedures, this study systematically reviewed the relevant literature and delineated the pathogenesis of contrast-induced nephropathy, which mainly includes renal medullary ischemia and hypoxia, direct toxicity to renal tubular epithelial cells, inflammatory response and imbalance of vasoactive substances, and hemorheological alterations. It also summarizes the risk prediction measures commonly used in clinical practice, such as precise identification of risk factors for contrast-induced nephropathy, the Mehran risk score and other predictive models, and biomarkers. Furthermore, preventive strategies are proposed to avoid the development of contrast-induced nephropathy through preoperative risk assessment and stringent evaluation of indications, hydration therapy, careful selection of contrast agents and strict control of dosage, and the use of pharmacological prophylaxis, with the aim of enhancing the safety of cerebrovascular interventional procedures.
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[2] Jing SW, Chen S, Lin WX, et al., 2024, New progress in the prevention of contrast induced nephropathy. Advances in Clinical Medicine, 14(4): 595-600.
[3] Chen HX, Wang S, 2023, Current status and progress of predictive models and related indicators for contrast induced nephropathy. Advances in Clinical Medicine, 13(11): 18418-18423.
[4] Tuersun T, Wei HY, Remutula N, et al., 2024, Diagnostic value of serum NLRP3 level and contrast medium dosage in contrast induced nephropathy after percutaneous coronary intervention in patients with acute ST segment elevation myocardial infarction. Chinese General Practice, 27(27): 3378-3382.
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[6] Wang CY, Yan GL, Wang D, et al., 2024, Effects of different inflammatory factors on contrast induced acute kidney injury after interventional therapy in patients with acute coronary syndrome. Journal of Southeast University (Medical Science Edition), 43(6): 811-821.
[7] Qi XM, An HL, Wang R, et al., 2023, Predictive analysis of UACR combined with serum KIM 1 and NGAL for postoperative contrast induced nephropathy in patients with coronary heart disease. Journal of Bengbu Medical College, 48(2): 178-181.
[8] Zhou L, Zhao Q, Wang F, 2022, Research progress on statins in the prevention and treatment of contrast induced nephropathy. Chinese Journal of Clinical Medicine, 29(2): 288-292.