ARTICLE

Volume 10,Issue 3

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26 September 2025

Research on the Interaction Mechanism of Molecular Signaling Pathways in Tumor Occurrence and Development in the Junction Area of Liver, Gallbladder, Pancreas and Spleen

Guodong Yu1
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1 Affiliated Hospital of Hebei University, Baoding 050031, Hebei, China
JMDS 2025 , 10(3), 42–47; https://doi.org/10.18063/JMDS.v10i3.651
© 2025 by the Author. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

Tumors in the junction area of the liver, gallbladder, pancreas and spleen are complex and highly fatal malignant tumors. Due to their involvement in multiple organs such as the liver, gallbladder, pancreas and spleen, they have become a tumor-prone area. In recent years, advancements in molecular biology have promoted in-depth research on the occurrence and development of tumors in this region, especially the interactions of molecular signaling pathways. The occurrence and progression of tumors are the result of the combined action of multiple signaling pathways. This article reviews the main molecular signaling pathways and their interaction mechanisms in tumors at the junction of the liver, gallbladder, pancreas and spleen, explores their roles in the tumor microenvironment, drug resistance and metastasis, and looks forward to future clinical applications.

Keywords
Tumor in the junction area of liver、gallbladder、pancreas and spleen
Molecular signaling pathway
Tumorigenesis
Interaction mechanism
Tumor microenvironment
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