Volume 11,Issue 1
Significance of Matrix Metalloproteinase-12 in Cervical Cancer: A Bioinformatics Analysis for Diagnosis, Prognosis
Introduction: Matrix metalloproteinase-12 (MMP12) plays an important role in suppressing tumor growth. MMP12 is associated with cervical squamous cell carcinoma (CESC). However, the correlation between MMP12 in conjunction with immune cell infiltration and its impact on the prognosis of CESC is unclear. Therefore, this research aimed to examine the transcriptional profile and predictive significance of MMP12 in CESC. Materials and methods: Gene expression patterns and clinical profiles of patients diagnosed with CESC were analyzed using the Cancer Genome Atlas database. Statistical analyses were performed to compare MMP12 expression between CESC and healthy cervical tissues. Functional enrichment was also performed. MMP12 methylation was analyzed using the EWAS database. Prognostic assessment was performed using Cox regression and Kaplan–Meier analyses. A nomogram was developed for forecasting overall survival. Conclusions: This research underscores the potential of MMP12 as a trusted indicator for diagnosing and predicting the expected outcome of CESC. Furthermore, MMP12 serves as a critical element in tumor invasion and evasion of the body’s protective system, highlighting its significance in the development of targeted therapies for CESC.
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