Objective: To analyze the effect of standardized continuous renal replacement therapy and personalized nursing in patients with renal failure. Method: Time period: March 2028–2024.8, sample size: 78 patients with continuous renal replacement therapy for renal failure were admitted to our hospital. The included samples were randomly divided into two groups using odd and even numbers. The control group consisted of 39 patients who received routine nursing care, while the observation group consisted of 39 patients who received personalized nursing care. The various indicators of the two groups were compared. Result: In the nursing satisfaction project, the observation group was at a higher level, and there was a significant difference in the actual data between the two groups (97.44%/79.49%), p < 0.05. In the renal function index project, the observation group is closer to the normal range, and there is a significant difference in the actual data (BUN, Scr, 24hUP) between the two groups, p < 0.05. In the incidence of complications project, the observation group was at a lower level, and there was a significant difference in the actual data between the two groups (2.56%/17.95%), p < 0.05.The statistical results showed that the observation group had lower blood pressure changes and edema symptoms, p < 0.05.In the research project on psychological resilience indicators, statistical results showed that the observation group had higher scores, p < 0.05. Conclusion: While implementing standardized continuous renal replacement therapy in patients with renal failure, adopting personalized care has significant advantages, especially in reducing patient complications, stabilizing blood pressure, relieving edema symptoms, and improving renal function. It is worth applying and promoting in clinical practice.