Volume 10,Issue 4
To Explore the Application Value of Paroxetine Hydrochloride Combined with Low-dose Atypical Antipsychotic Drugs in the Treatment of Elderly Patients with Depression
Objective: To explore the application value of paroxetine hydrochloride combined with low-dose atypical antipsychotics (olanzapine is selected) in the treatment of elderly patients with depression. Methods: 70 elderly patients with depression who were treated in our hospital from January 2022 to December 2023 were selected and divided into two groups using the random number table method, with 35 cases in each group. The single medication group was treated only with paroxetine hydrochloride, while the combined medication group was treated with paroxetine hydrochloride combined with low-dose olanzapine. The therapeutic effects of the two groups were compared. Results: The post-treatment depression scale (HAMD) score of the combined medication group was lower than that of the single medication group, the total effective rate of treatment was higher than that of the single medication group, and the incidence of adverse reactions was lower than that of the single medication group (p < 0.05). Conclusion: Paroxetine hydrochloride combined with low-dose atypical antipsychotics in the treatment of elderly patients with depression can effectively improve depressive symptoms and improve treatment effects, and is highly safe and has important clinical application value.
[1] Tang C, Wang X, 2025, Analysis of the Effect of Paroxetine Hydrochloride Combined with Low-Dose Atypical Antipsychotic Drugs in the Treatment of Elderly Patients with Depression. Chinese and Foreign Medical Research, 4(9): 73–75.
[2] Zhou P, 2021, To Explore the Effect of Paroxetine Hydrochloride Combined with Low-Dose Atypical Antipsychotic Drugs in the Treatment of Geriatric Depression—Comment on “Geriatric Depression”. Chinese Clinical Pharmacology and Therapeutics, 26(8): 975.
[3] Liu Y, 2021, The Application Value of Paroxetine Hydrochloride Combined with Low-Dose Atypical Antipsychotic Drugs in Elderly Patients with Depression. Modern Chinese Doctors, 59(21): 30–33.
[4] Zhang H, 2020, Study on the Effect of Paroxetine Hydrochloride Combined with Low-Dose Atypical Antipsychotic Drugs in the Treatment of Elderly Depression. Chinese Community Physicians, 36(12): 96–97.
[5] Sun P, 2020, Analysis of the Efficacy and Safety of Paroxetine Hydrochloride Combined with Atypical Antipsychotics in the Treatment of Elderly Depression. Primary Medicine Forum, 24(11): 1508–1509.
[6] Yu X, 2019, Analysis of the Efficacy of Paroxetine Combined with Low-Dose Atypical Antipsychotics on Elderly Depression. Chinese Medical Guide, 17(33): 138–139.
[7] Lei L, 2019, Clinical Controlled Study of Paroxetine Combined with Low-Dose Atypical Antipsychotics in the Treatment of Elderly Depression. Chinese Medical Guide, 17(16): 157.
[8] Cao T, 2016, Efficacy and Safety of Paroxetine Combined with Low-Dose Atypical Antipsychotics or Paroxetine Alone in the Treatment of Elderly Depression. Chinese Medical Guide, 14(23): 119.