Volume 10,Issue 4
Clinical Observation on the Efficacy of Bufei Yishen Decoction in Improving Pulmonary Function in Patients with Stable Chronic Obstructive Pulmonary Disease
Objective: To investigate the impact of Bufei Yishen Decoction on enhancing pulmonary function in patients with stable Chronic Obstructive Pulmonary Disease (COPD), and to offer theoretical and practical references for TCM clinical treatment. Methods: A total of 80 patients with stable COPD who received treatment from January 2024 to December 2024 were enrolled and randomly assigned to the control group and the observation group via a random number table, with 40 cases in each group. The control group was given conventional Western medicine therapy, while the observation group received Bufei Yishen Decoction combined with the same Western medicine treatment as the control group. Both groups underwent continuous treatment for 12 weeks. Before and after treatment, comparisons were made between the two groups regarding pulmonary function indices [Forced Expiratory Volume in 1 Second (FEV1), Forced Vital Capacity (FVC), FEV1/FVC], TCM syndrome scores, and quality of life scores (St. George’s Respiratory Questionnaire, SGRQ). Results: Prior to treatment, there were no statistically notable disparities in FEV1, FVC, and FEV1/FVC between the two groups (p > 0.05); after 12 weeks of treatment, the observation group exhibited significantly higher values of FEV1 (2.31 ± 0.42 L), FVC (3.15 ± 0.58 L), and FEV1/FVC (68.25 ± 7.13%) compared with the control group [FEV1 (1.85 ± 0.36 L), FVC (2.62 ± 0.45 L), FEV1/FVC (60.18 ± 6.57%)], and these differences were statistically significant (p < 0.05). Before treatment, no statistically significant differences were found in TCM syndrome scores (covering cough, expectoration, shortness of breath, fatigue, soreness and weakness of waist and knees) and SGRQ scores between the two groups (p > 0.05); after treatment, the total TCM syndrome score of the observation group (5.23 ± 1.85 points) was remarkably lower than that of the control group (9.68 ± 2.36 points), and the SGRQ score (28.56 ± 6.32 points) was also significantly lower than that of the control group (45.89 ± 7.15 points), with statistically significant differences (p < 0.05). Conclusion: The combination of Bufei Yishen Decoction and conventional Western medicine can notably improve the pulmonary function of patients with stable COPD, alleviate TCM syndrome manifestations, and enhance patients’ quality of life, which is worthy of clinical popularization and application.
[1] Liu N, Wang L, Li Y, et al., 2025, Effect of Electroacupuncture on Pulmonary Inflammation in Mice with Chronic Obstructive Pulmonary Disease by Regulating Alveolar Macrophage Polarization via Vagus Nerve. Journal of Nanjing University of Chinese Medicine, 2025(10): 1356–1364.
[2] Xie Q, Zhai S, Ye J, et al., 2025, Early Warning Value of Serum DcR3 Combined with Urinary L-FABP for Prognosis of Patients with AECOPD Complicated with Respiratory Failure Treated by Non-Invasive Ventilation. Guangdong Medical Journal, 46(10):1560–1566.
[3] Tan Y, Qiu C, 2025, Analysis of Support Needs for Relieving Dyspnea Fear in Patients with Acute Exacerbation of COPD Based on Kano Model. Shanghai Nursing, 25(10): 6–11.
[4] Liu C, 2025, Efficacy of Combined Detection of Fibrinogen and D-Dimer Levels in the Diagnosis of Bacterial Infection in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Journal of Typical Cases, 1–7.
[5] Chai Y, Zhou X, 2025, Observation on the Efficacy of Zengye Chengqi Decoction in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Constipation. Zhejiang Journal of Traditional Chinese Medicine, 60(10): 877–878.
[6] Zhang Z, Wang Y, Fang L, et al., 2025, Clinical Observation on the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease of Phlegm-Heat Obstructing the Lung Type Complicated with Gastrointestinal Dysfunction by Xiebai Powder Combined with Tiaowei Chengqi Decoction. Zhejiang Journal of Traditional Chinese Medicine, 60(10): 875–876.
[7] Fan S, 2025, How to Correctly Care for Patients with Chronic Obstructive Pulmonary Disease in Daily Life? Health Must-Read, 2025(29): 143–144.
[8] Pan J, Yang S, Wang Y, 2025, Discussion on the Etiology, Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease Based on the Geographical Characteristics of Cold Regions. Jiangxi Journal of Traditional Chinese Medicine, 56(10): 7–9 + 13.
[9] Huang H, Li Y, Han X, et al., 2025, Exploration of the Scientific Connotation of “Strengthening the Earth to Generate Metal” Method in the Treatment of Chronic Obstructive Pulmonary Disease Based on the “Gut-Lung Axis” Theory. China Journal of Chinese Materia Medica, 1–10.
[10] Yan M, Huang P, Tan T, 2025, Clinical Efficacy of Miao Medicine Aidi Tea Decoction Combined with Auricular Point Pressing Therapy in the Treatment of Chronic Obstructive Pulmonary Disease. Journal of Chengdu Medical College, 1–7.
[11] Fan P, Cui H, Liu K, et al., 2025, Predictive Value of Serum hs-CRP/PA Ratio, LIN28B, and HDAC2 for Poor Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Laboratory Medicine and Clinic, 22(19): 2606–2611.
[12] Wu C, Wang C, Hu H, 2025, Predictive Value of Serum DcR3 and HDAC2 for Poor Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Laboratory Medicine and Clinic, 22(19): 2623–2627 + 2632.
[13] Pan Y, Wang Y, Guo R, 2026, Application Effect of Group Peer Support Intervention Strategy Based on Cognitive Goal Implementation Concept in Patients with Chronic Obstructive Pulmonary Disease in Rehabilitation Stage. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 34(01):114–119.
[14] Wu F, Chen Q, 2025, Construction of a Nomogram Prediction Model for Poor Prognosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Journal of Qiqihar Medical University, 46(19): 1890–1894.
[15] Liu H, He G, Wei J, et al., 2025, Correlation Between Diaphragm Mobility and Cardiopulmonary Function in Patients with Chronic Obstructive Pulmonary Disease Complicated with Heart Failure. Clinical Misdiagnosis & Mistherapy, 38(19): 56–62.
[16] Chen G, Xie R, Huang C, et al., 2025, Mechanism of Buyuan Decoction in Regulating Oxidative Stress to Treat Skeletal Muscle Atrophy in COPD Rats via P62/Keap1/Nrf2 Signaling Pathway. Lishizhen Medicine and Materia Medica Research, 1–6.
[17] Zhang J, Dang Y, 2025, Relationship Between Intestinal Flora and Its Metabolites and Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Aerospace Medicine, 36(10): 1174–1176.
[18] Deng X, 2025, Effect of Graded Exercise Pulmonary Rehabilitation Intervention Combined with Breathing Exercises on Pulmonary Function and CAT, SGRQ Scores in Patients With COPD. Chinese Journal of Modern Drug Application, 19(21): 169–172.