Volume 10,Issue 4
Research Progress and Clinical Translation of Vitamin AD in the Prevention and Treatment of Allergic Diseases in Children
The incidence of allergic diseases in children continues to rise, posing a significant public health challenge. Vitamin AD, as a critical nutrient, has increasingly demonstrated its pivotal role in the synergistic regulation of immune homeostasis, in addition to its classical functions. This study, based on clinical data analysis of 696 enrolled children, reveals a high prevalence of vitamin D insufficiency/deficiency at 64% (446/696) and vitamin A deficiency at 48% (331/696), particularly pronounced among children with recurrent respiratory infections and allergic diseases. Notably, even among those regularly supplemented with vitamin AD drops, a substantial proportion of children still exhibit deficiencies, underscoring the necessity for precise monitoring and individualized supplementation, and providing a crucial target for clinical intervention. Substantial evidence indicates a strong correlation between vitamin AD deficiency and the high incidence of allergic diseases in children. Through mechanisms such as synergistically regulating the Th1/Th2 imbalance, promoting Treg cell-mediated immune tolerance, enhancing the intestinal mucosal barrier, and inhibiting abnormal inflammatory responses, vitamin AD plays a key role in the prevention and treatment of allergic diseases. This article systematically reviews the immunomodulatory mechanisms of vitamin AD (especially its synergistic effects), the latest research progress in the prevention and treatment of common pediatric allergic diseases, existing controversies, and clinical translation pathways based on the concept of precision medicine, aiming to provide a scientific basis and actionable strategies for constructing a precise and efficient prevention and treatment system for pediatric allergic diseases.
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